Integrated Gene-to-Structure services

Through Shamrock Structures’ internal scientific staff and its alliances with network partners we possess the multi-disciplinary scientific capabilities and access to key technologies to conduct full service structural biology programs.

We offer the option to purchase a comprehensive package of integrated gene-to-structure services or to choose specific individual services and technologies along the structural biology pathway. Our services include:

• DNA cloning
• Protein expression
• Purification
• Crystallization (including co-crystallization with lead compounds)
• X-ray data collection
• Structure determination

Depending on your stage of progress in the discovery program, your own core competencies, and your partnering philosophies, Shamrock Structures accommodates your needs by being flexible in structuring agreements of varying breadths and time frames.

Shamrock Structures’ goal is to provide services and technologies that enable its clients to reach their objectives rapidly and cost effectively through structure-based techniques.

How it works: YOU name the target WE do the gene to structure You input as you see fit (or not at all)

Advantages of Shamrock Structures

• A decade of big Pharma gene to structure and project management experience
• Specialize in construct design and protein biochemistry for structural biology
• Industry developed experience + proprietary "ConstructExpress" methodology
• Growing internal infrastructure for protein expression and purification
• Formal strategic partnerships with a CRO network to provide extended capacity featuring:
• A China-based CRO with proven competency in MB, protein production, assay design, and scalable synthesis
• Blue Sky Biotechnology: a significant & growing US-based biotech provider of all protein production services
• Several Chicago-area Universities

We are your single point of contact for a network of services to meet your structural biology outsourcing needs!